Major Depressive Disorder Case Study


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Disorders With Affective Components

Therapy for Patients With Major Depressive Disorder (MDD) 


Required Readings

Baek, J. H., Nierenberg, A. A., & Fava, M. (2016). Pharmacological approaches to treatment-resistant depression. In T. A. Stern, M. Favo, T. E. Wilens, & J. F. Rosenbaum. (Eds.), Massachusetts General Hospital psychopharmacology and neurotherapeutics (pp. 44–47). Elsevier.

Fava, M., & Papakostas, G. I. (2016). Antidepressants. In T. A. Stern, M. Favo, T. E. Wilens, & J. F. Rosenbaum. (Eds.), Massachusetts General Hospital psychopharmacology and neurotherapeutics (pp. 27–43). Elsevier.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).

Howland, R. H. (2008a). Sequenced Treatment Alternatives to Relieve Depression (STAR*D). Part 1: Study design. Journal of Psychosocial Nursing and Mental Health Services, 46(9), 21–24.

Howland, R. H. (2008b). Sequenced Treatment Alternatives to Relieve Depression (STAR*D). Part 2: Study outcomes. Journal of Psychosocial Nursing and Mental Health Services, 46(10), 21–24.

Lorberg, B., Davico, C., Martsenkovskyi, D., & Vitiello, B. (2019). Principles in using psychotropic medication in children and adolescents. In J. M. Rey & A. Martin (Eds.), IACAPAP e-textbook of child and adolescent mental health. 873b0e58d493684a07/A.7-Psychopharmacology-2019.1.pdf

Magellan Health. (2013). Appropriate use of psychotropic drugs in children and adolescents: A clinical monograph.…

Poznanski, E. O., & Mokros, H. B. (1996). Child depression rating scale—Revised. Western Psychological Services. Rao, U. (2013). Biomarkers in pediatric depression. Depression & Anxiety, 30(9), 787–791.

Yasuda, S. U., Zhang, L. & Huang, S.-M. (2008). The role of ethnicity in variability in response to drugs: Focus on clinical pharmacology studies. Clinical Pharmacology & Therapeutics, 84(3), 417–423. wnloads/Drugs/ScienceResearch/…/UCM085502.pdf

Medication Resources 

U.S. Food & Drug Administration. (n.d.). Drugs@FDA: FDA-approved drugs.

Note: To access the following medications, use the Drugs@FDA resource. Type the name of each medication in the keyword search bar. Select the hyperlink related to the medication name you searched. Review the supplements provided and select the package label resource file associated with the medication you searched. If a label is not available, you may need to conduct a general search outside of this resource provided. Be sure to review the label information for each medication as this information will be helpful for your review in preparation for your Assignments.

Review the following medications: 

amitriptyline • bupropion • citalopram • clomipramine • desipramine • desvenlafaxine • doxepin • duloxetine • escitalopram • fluoxetine • fluvoxamine • imipramine • ketamine • mirtazapine • nortriptyline • paroxetine • selegiline • sertraline • trazodone • venlafaxine • vilazodone • vortioxetine

Required Media

Doc Snipes. (2022, April 13). Major depressive disorders in the DSM 5 TR [Video]. YouTube.

Psych Hub. (2020, October 5). Social determinants of health [Video]. 


Assessing and Treating Vulnerable Populations for Depressive Disorders 

The Assignment 5 pages 

For this assignment, you will develop a patient medication guide for treatment of depressive disorders in a vulnerable population (your choice for one vulnerable patient population to choose from: children, adolescents, older adults, dementia patients, pregnant women or one not listed of your choice!). Be sure to use language appropriate for your audience (patient, caregiver, parent, etc.). You will include noncopyright images and/or information tables to make your patient medication guide interesting and appealing. Limit your patient medication guide to 5 pages. You will create this guide as an assignment; therefore, a title page, introduction, conclusion, and reference page are required. You must include a minimum of 3 scholarly supporting resources outside of your course provided resources.

In your patient guide, include discussion on the following:

• Depressive disorder causes and symptoms

• How depression is diagnosed for the vulnerable population of your choice, why is this population considered vulnerable 

Medication treatment options including risk vs benefits; side effects; FDA approvals for the vulnerable population of your choice 

Medication considerations of medication examples prescribed (see last bullet item) 

What is important to monitor in terms of labs, comorbid medical issues with why important for monitoring 

Special Considerations (you must be specific, not general and address at least one for EACH category; you must demonstrate critical thinking beyond basics of HIPPA and informed consent!): legal considerations, ethical considerations, cultural considerations, social determinants of health 

  • Where to follow up in your local community for further information

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